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Abstract <p><b>Objective:</b> The field of regenerative medicine is witnessing a surge in the recognition and utilization of self-assembling peptides (SAPs). The creation of sophisticated biomaterials for local medication administration and tissue engineering applications has entered a new age thanks to molecular self-assembly. Self-assembling peptides (SAPs), which are naturally biocompatible and biodegradable, have gained attention for these uses. <b>Methods:</b> The present investigation will focus on the examination of brief and water-soluble SAP biomaterials that exhibit enhanced pharmacokinetic and pharmacodynamic reactions subsequent to the topical delivery of therapeutic systems. Additionally, these biomaterials may also possess improved regenerative capabilities for use in tissue engineering applications. <b>Results and Discussion:</b> While peptide engineering is a method frequently used to incorporate the required features into composite biomaterials, SAPs are capable of producing supramolecular structures utilizing an infinite variety of building components. <b>Conclusions:</b> Together, these two components broaden the range of SAPs’ multifunctionality, making them powerful biomaterials suitable for use in a variety of biological applications.</p>

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Application of Self-Assembly Peptides in Tissue Engineering (A Review)

  • 期刊论文

  • 发表日期：

    2025年1月20日

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  • Mohammad Kaka,
  • Arash Abdolmaleki,
  • Asadollah Asadi

摘要

Abstract

Objective: The field of regenerative medicine is witnessing a surge in the recognition and utilization of self-assembling peptides (SAPs). The creation of sophisticated biomaterials for local medication administration and tissue engineering applications has entered a new age thanks to molecular self-assembly. Self-assembling peptides (SAPs), which are naturally biocompatible and biodegradable, have gained attention for these uses. Methods: The present investigation will focus on the examination of brief and water-soluble SAP biomaterials that exhibit enhanced pharmacokinetic and pharmacodynamic reactions subsequent to the topical delivery of therapeutic systems. Additionally, these biomaterials may also possess improved regenerative capabilities for use in tissue engineering applications. Results and Discussion: While peptide engineering is a method frequently used to incorporate the required features into composite biomaterials, SAPs are capable of producing supramolecular structures utilizing an infinite variety of building components. Conclusions: Together, these two components broaden the range of SAPs’ multifunctionality, making them powerful biomaterials suitable for use in a variety of biological applications.