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Abstract <p>This study investigates the anticonvulsant effects of <i>Zingiber officinale</i> on seizures, memory loss, depression, and hippocampal sclerosis in a temporal lobe epilepsy with hippocampus sclerosis (TLE-HS) model, a common form of drug-resistant epilepsy. A total of 21 Sprague-Dawley rats were divided into three groups: 1) Control (saline-treated), 2) Diseased (Lithium–Pilocarpine model + saline), and 3) Treated (Lithium–Pilocarpine model + <i>Z. officinale</i>). After TLE-HS induction, rats received oral treatments for 15 days. Seizures were monitored via Video/EEG for 15 days/24 h, behavioral tests assessed memory and depression (24 hours following the final monitoring session), and Nissl staining evaluated hippocampal neurons. The <i>Z.&#xa0;officinale</i> extract significantly reduced seizure frequency (<i>p</i> &lt; 0.05), alleviated depressive symptoms (<i>p</i> &lt; 0.05), and enhanced memory function (<i>p</i> &lt; 0.05). Notably, treatment with <i>Z. officinale</i> provided significant neuroprotection in the Lithium–Pilocarpine-induced TLE-HS rat model. <i>Z. officinale</i> extract significantly reduced seizure frequency, alleviates depression, improves memory, and offers partial neuroprotection. Further studies are needed to elucidate its mechanism and potential for treating TLE-HS in humans.</p>

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Zingiber officinale Attenuates Seizure Frequency, Depression-Like Behavior and Memory Impairment in Experimental Temporal Lobe Epilepsy via Hippocampal Neuroprotection

  • 期刊论文

  • 发表日期：

    2026年7月19日

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  • Muhammad Wasim,
  • Mehr Musani,
  • Hasan Salman Siddiqi,
  • Mahwish Fatima,
  • Syeda Arfa Mairaj,
  • Saara Ahmad,
  • Fazal Manzoor Arain

摘要

Abstract

This study investigates the anticonvulsant effects of Zingiber officinale on seizures, memory loss, depression, and hippocampal sclerosis in a temporal lobe epilepsy with hippocampus sclerosis (TLE-HS) model, a common form of drug-resistant epilepsy. A total of 21 Sprague-Dawley rats were divided into three groups: 1) Control (saline-treated), 2) Diseased (Lithium–Pilocarpine model + saline), and 3) Treated (Lithium–Pilocarpine model + Z. officinale). After TLE-HS induction, rats received oral treatments for 15 days. Seizures were monitored via Video/EEG for 15 days/24 h, behavioral tests assessed memory and depression (24 hours following the final monitoring session), and Nissl staining evaluated hippocampal neurons. The Z. officinale extract significantly reduced seizure frequency (p < 0.05), alleviated depressive symptoms (p < 0.05), and enhanced memory function (p < 0.05). Notably, treatment with Z. officinale provided significant neuroprotection in the Lithium–Pilocarpine-induced TLE-HS rat model. Z. officinale extract significantly reduced seizure frequency, alleviates depression, improves memory, and offers partial neuroprotection. Further studies are needed to elucidate its mechanism and potential for treating TLE-HS in humans.