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Abstract <p>Postoperative cognitive dysfunction (POCD) is a common neurological complication following surgery and anesthesia. This study primarily investigates the expression and diagnostic value of serum miR-153-3p in ageing patients with POCD. A total of 150 ageing patients with fractures and osteoarthritis who underwent unilateral total hip arthroplasty under general anesthesia, were included in the study. Based on the Mini-Mental State Examination (MMSE) score, these patients were divided into two groups: the POCD group and the non-POCD (NPOCD) group. Quantitative real-time fluorescence PCR was utilized to determine serum levels of miR-153-3p. The predictive efficacy was analyzed using receiver operating characteristic curves. Pearson correlation analysis was employed to assess correlations, and binary logistic analysis was conducted to identify risk factors associated with POCD. Our findings show that miR-153-3p levels in ageing patients decline significantly from the third day post-anesthesia. Compared with the NPOCD group, the miR-153-3p level in the POCD group dropped significantly. Serum miR-153-3p in POCD patients correlates positively with MMSE scores. Furthermore, low levels of miR-153-3p appears to be a contributing factor in the development of postoperative POCD. In conclusion, low serum miR-153-3p levels in ageing patients on the third day after general anesthesia may be a sensitive biochemical marker for POCD occurrence.</p>

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Prediction Value of hsa-miR-153-3p for Early Cognitive Function and Short-Term Clinical Outcome after Anesthesia in Older People

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • Yuansong Lan,
  • Bei Wang,
  • Ming Zhang

摘要

Abstract

Postoperative cognitive dysfunction (POCD) is a common neurological complication following surgery and anesthesia. This study primarily investigates the expression and diagnostic value of serum miR-153-3p in ageing patients with POCD. A total of 150 ageing patients with fractures and osteoarthritis who underwent unilateral total hip arthroplasty under general anesthesia, were included in the study. Based on the Mini-Mental State Examination (MMSE) score, these patients were divided into two groups: the POCD group and the non-POCD (NPOCD) group. Quantitative real-time fluorescence PCR was utilized to determine serum levels of miR-153-3p. The predictive efficacy was analyzed using receiver operating characteristic curves. Pearson correlation analysis was employed to assess correlations, and binary logistic analysis was conducted to identify risk factors associated with POCD. Our findings show that miR-153-3p levels in ageing patients decline significantly from the third day post-anesthesia. Compared with the NPOCD group, the miR-153-3p level in the POCD group dropped significantly. Serum miR-153-3p in POCD patients correlates positively with MMSE scores. Furthermore, low levels of miR-153-3p appears to be a contributing factor in the development of postoperative POCD. In conclusion, low serum miR-153-3p levels in ageing patients on the third day after general anesthesia may be a sensitive biochemical marker for POCD occurrence.