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Abstract <p>The review provides information on the development of peptide drugs for the treatment of Alzheimer’s disease, a progressive neurodegenerative disease, the main cause of senile dementia. The target of the peptides was the pathological aggregation of the tau protein, leading to the formation of neurofibrillary tangles and, ultimately, the death of neurons. The peptides were designed based on computer modeling of the structural correspondence to the tau protein binding sites responsible for the formation of neurofibrillary aggregates, and using phage display technology. Peptide inhibitors have also been proposed to inhibit the activity of protein kinases involved in pathological transformations of tau protein. Peptides as potential therapeutic agents for the treatment of Alzheimer’s disease have undoubted advantages as non-toxic, accessible, and capable of binding to target proteins with high selectivity and affinity.</p>

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Peptide Inhibitors of the Tau Protein Aggregation in Alzheimer’s Disease

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • V. P. Martinovich,
  • O. V. Gribovskaya

摘要

Abstract

The review provides information on the development of peptide drugs for the treatment of Alzheimer’s disease, a progressive neurodegenerative disease, the main cause of senile dementia. The target of the peptides was the pathological aggregation of the tau protein, leading to the formation of neurofibrillary tangles and, ultimately, the death of neurons. The peptides were designed based on computer modeling of the structural correspondence to the tau protein binding sites responsible for the formation of neurofibrillary aggregates, and using phage display technology. Peptide inhibitors have also been proposed to inhibit the activity of protein kinases involved in pathological transformations of tau protein. Peptides as potential therapeutic agents for the treatment of Alzheimer’s disease have undoubted advantages as non-toxic, accessible, and capable of binding to target proteins with high selectivity and affinity.