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<p>Post-stroke cognitive impairment (PCI) is a common complication after ischemic stroke (IS). There is evidence that their development is largely due to regulatory and structural changes in neuroendocrine systems involved in the body’s adaptation to stress. Stress-related clinical and biochemical parameters were analyzed in 14 patients with normal cognitive status after IS, in 15 patients with mild cognitive impairment after IS, and in 10 people without stroke of the appropriate age and gender. The indicators were evaluated in the first days, a month later, six months later, and a year after IS. Using the logistic regression method, it was shown that a simultaneous decrease in the level of cortisol in hair and the level of adrenocorticotropic hormone (ACTH) in blood plasma six months after IS predicts a high probability of an unfavorable prognosis for the cognitive status of patients in the late post-stroke period. The data confirm previously obtained results indicating a significant contribution of stress-realizing systems in the development of post-stroke cognitive impairment.</p>

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Impaired Cognitive Function in Late Post-Stroke Period Correlates with the Levels of Adrenocorticotropic Hormone and Hair Cortisol

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月1日

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  • T. A. Druzhkova,
  • M. Yu. Zhanina,
  • E. E. Vladimirova,
  • A. B. Guekht,
  • N. V. Gulyaeva

摘要

Post-stroke cognitive impairment (PCI) is a common complication after ischemic stroke (IS). There is evidence that their development is largely due to regulatory and structural changes in neuroendocrine systems involved in the body’s adaptation to stress. Stress-related clinical and biochemical parameters were analyzed in 14 patients with normal cognitive status after IS, in 15 patients with mild cognitive impairment after IS, and in 10 people without stroke of the appropriate age and gender. The indicators were evaluated in the first days, a month later, six months later, and a year after IS. Using the logistic regression method, it was shown that a simultaneous decrease in the level of cortisol in hair and the level of adrenocorticotropic hormone (ACTH) in blood plasma six months after IS predicts a high probability of an unfavorable prognosis for the cognitive status of patients in the late post-stroke period. The data confirm previously obtained results indicating a significant contribution of stress-realizing systems in the development of post-stroke cognitive impairment.