Abstract <p>Addressing the complexities of treating neurological disorders requires innovative therapeutic approaches. One compound of significant interest is crocetin, derived from saffron, renowned for its medicinal properties, especially its neuroprotective effects. This study employs a molecular docking approach to examine crocetin’s therapeutic potential across various neurological disorders. Molecular docking simulations were conducted to predict the binding affinity and interactions between crocetin and target proteins associated with neurological disorders. The study also delved into the structural requirements necessary for effective binding. Molecular docking outcomes disclosed robust binding interactions and favorable affinities between crocetin and target proteins implicated in various neurological disorders, including Alzheimer’s disease, Parkinson’s disease, epilepsy, and depression. The predicted binding modes provided insights into the crucial molecular interactions governing the ligand-protein complexes. The findings propose crocetin as a promising therapeutic approach for multiple neurological disorders. The molecular docking approach employed in this study serves as a valuable tool for rational drug design and optimization of crocetin based compounds. Further experimental validation and preclinical studies are imperative to affirm the efficacy and safety of crocetin as a potential treatment option, paving the way for the development of more effective and targeted therapies for neurological disorders.</p>