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<p>The combined model of the effects of deep space flight factors, which was developed at the IBMP RAS, includes ground-based modeling of the chronic synchronous effects of hypogravity and gamma radiation, supplemented by heavy ion irradiation, a key risk factor of interplanetary flights. At the behavioral level, the result of these factors is a spectrum of disorders in the emotional sphere while maintaining cognitive abilities. Neurochemical studies in rats show multidirectional changes in the metabolism of key neurotransmitters, primarily dopamine and serotonin, both in the old brain and prefrontal cortex. At the molecular level, there are changes in the expression of genes encoding the corresponding receptors. A malfunction of the dopaminergic system apparently causes emotional and behavioral disorders. Folic acid, a precursor of dopamine, corrects these changes and, thus, opens up the possibility for further search for means of prevention and treatment of the emerging pathology.</p>

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Molecular and Neurochemical Mechanisms of CNS Response to Combined Exposure to Model Factors of Spaceflight in Rodents

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • O. S. Kuznetsova,
  • A. A. Perevezentsev,
  • P. L. Naplekova,
  • V. V. Yasnetsov,
  • A. S. Shtemberg

摘要

The combined model of the effects of deep space flight factors, which was developed at the IBMP RAS, includes ground-based modeling of the chronic synchronous effects of hypogravity and gamma radiation, supplemented by heavy ion irradiation, a key risk factor of interplanetary flights. At the behavioral level, the result of these factors is a spectrum of disorders in the emotional sphere while maintaining cognitive abilities. Neurochemical studies in rats show multidirectional changes in the metabolism of key neurotransmitters, primarily dopamine and serotonin, both in the old brain and prefrontal cortex. At the molecular level, there are changes in the expression of genes encoding the corresponding receptors. A malfunction of the dopaminergic system apparently causes emotional and behavioral disorders. Folic acid, a precursor of dopamine, corrects these changes and, thus, opens up the possibility for further search for means of prevention and treatment of the emerging pathology.