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Abstract <p>There is a lack of comprehensive research on intensive care unit acquired weakness (ICU-AW), which hinders the early detection and diagnosis of this condition. This study aims to investigate the diagnostic and prognostic significance of miR-140-5p in ICU-AW patients and assess its potential utility as a biomarker for ICU-AW. The expression level of miR-140-5p was assessed using real-time quantitative PCR in ICU-AW patients. The diagnostic and prognostic value of miR-140-5p in ICU-AW patients was evaluated through ROC curve, correlation, Cox regression, and Kaplan–Meier survival analysis. Additionally, the target gene of miR-140-5p was predicted, followed by enrichment analysis on the Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. The expression of miR-140-5p was up-regulated in ICU-AW patients and showed a significant association with MRC and SOFA sores. miR-140-5p demonstrated potential diagnostic utility in discriminating ICU-AW patients from the controls. ICU-AW patients exhibiting low miR-140-5p expression levels tended to have a more favorable prognosis. Enrichment analyzed based on GO and KEGG suggested miR-140-5p might facilitate intercellular communication via exosomes. The miR-140-5p exhibits promise as a potential biomarker for diagnosing and prognosticating the outcomes of ICU-AW.</p>

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Diagnostic and Prognostic Value of miR-140-5p in Patients with ICU-Acquired Weakness

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • Peng-Hui Du,
  • Qi-Qi Wu,
  • Zi-Hui Xu,
  • Zhi-Hong Xu,
  • Qing-Liu Zheng

摘要

Abstract

There is a lack of comprehensive research on intensive care unit acquired weakness (ICU-AW), which hinders the early detection and diagnosis of this condition. This study aims to investigate the diagnostic and prognostic significance of miR-140-5p in ICU-AW patients and assess its potential utility as a biomarker for ICU-AW. The expression level of miR-140-5p was assessed using real-time quantitative PCR in ICU-AW patients. The diagnostic and prognostic value of miR-140-5p in ICU-AW patients was evaluated through ROC curve, correlation, Cox regression, and Kaplan–Meier survival analysis. Additionally, the target gene of miR-140-5p was predicted, followed by enrichment analysis on the Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. The expression of miR-140-5p was up-regulated in ICU-AW patients and showed a significant association with MRC and SOFA sores. miR-140-5p demonstrated potential diagnostic utility in discriminating ICU-AW patients from the controls. ICU-AW patients exhibiting low miR-140-5p expression levels tended to have a more favorable prognosis. Enrichment analyzed based on GO and KEGG suggested miR-140-5p might facilitate intercellular communication via exosomes. The miR-140-5p exhibits promise as a potential biomarker for diagnosing and prognosticating the outcomes of ICU-AW.