Clinical Value of lncRNA MALAT1 and miR-154-5p in the Severity and Prognosis of Convulsive Status Epilepticus

Convulsive status epilepticus (CSE) is a common pediatric emergency that can lead to irreversible brain damage and high mortality rates. This study focused on the clinical value of lncRNA MALAT1 and miR-154-5p in assessing the severity and prognosis of CSE. Significant differences were found in clinical indicators between the CSE and healthy groups. RT-qPCR detected noticeably increased MALAT1 levels and decreased miR-154-5p levels in the serum of children with CSE. Pearson analysis revealed that MALAT1 and miR-154-5p were strongly linked to oxidative stress, inflammation, neurological damage, and apoptosis. The ROC curves showed that MALAT1 and miR-154-5p had high sensitivity and specificity in distinguishing CSE patients from healthy children. Multivariate logistic regression analysis identified MALAT1 and miR-154-5p as risk factors for poor prognosis in CSE. A total of 73 potential target genes of miR-154-5p were predicted from public databases. These genes and their associated signaling pathways could be crucial for CSE progression. In conclusion, MALAT1 and miR-154-5p were associated with CSE severity and had promising diagnostic and prognostic value for CSE.