Anxious and Melancholic Depression Are Associated with Oppositely Directed Changes in Serum Albumin Conformation

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发表日期：

2024年3月1日

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M. G. Uzbekov,
N. V. Smolina,
T. I. Syrejshchikova,
N. M. Maximova,
S. N. Shikhov,
G. E. Dobretsov,
V. V. Brilliantova,
V. V. Krjukov

摘要

Abstract—The study was aimed at investigating the peculiarities of the conformational changes in serum albumin in patients with anxious and melancholic depression. Albumin conformation was measured by the method of the subnanosecond laser time resolved fluorescence spectroscopy. Anxious depression was accompanied by a significant decrease in the values of the three amplitudes of the serum albumin in comparison with controls. In the melancholic depression, the values of all three amplitudes of serum albumin molecules were significantly elevated in comparison with controls. These results clearly indicate that anxious and melancholic depression are accompanied by oppositely directed changes in serum albumin conformation.