Promising Markers of Neuroinflammation in Schizophrenia

Abstract—There is no single model for the pathogenesis of schizophrenia, but neuroinflammation is considered a key mechanism in the development of this disease. The aim of our study was to analyze and summarize the literature data on the role of neuroinflammation markers in schizophrenia. We used the keywords “neuroinflammation,” “cytokines,” “chemokines,” “microcirculation,” “microglia,” “neurodestruction,” and “schizophrenia” to search for the articles published in 1990–2023 in the PubMed and e-Library.ru databases. The review discusses an integrated approach to the concept of neuroinflammation in schizophrenia with regard to known and promising markers. Studies, including those of the authors of the article, indicate a significant role of microcirculation disorders and endothelial dysfunction, cytokines and chemokines, and neurodestruction in the mechanisms of development and course of schizophrenia. The presented results require more detailed studies to establish new neurobiological and pathogenetic functions of neuroinflammation in schizophrenia.