Scholarlink

Abstract <p>NK cells participate in the antimicrobial immune response. NK cell activation by bacterial polysaccharides (PSs) can occur indirectly through signals from other immune cells or through direct influence of PSs on NK cells via interaction with activating receptors. This study demonstrated that peripheral NK cells bind fluorescently labeled PSs from the Gram-negative bacteria <i>Escherichia coli</i>, <i>Shigella flexneri</i>, and <i>Pseudomonas aeruginosa</i> with varying efficiency depending on the PS origin and the NK cell donor. PSs from <i>Escherichia coli</i> strain O19ab induced an increased IFN-γ production by NK cells in the absence of high levels of PS binding to the cell surface. The obtained results provide new insights into the interactions of NK cells with polysaccharides and open new prospects for understanding the NK cell-mediated immune response to bacterial infections.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Interaction of Human Peripheral NK Cells with Bacterial Polysaccharides

  • 期刊论文

  • 发表日期：

    2025年12月1日

查看全文
  • A. A. Boyko,
  • L. M. Kanevskiy,
  • E. M. Rapoport,
  • A. B. Tuzikov,
  • N. V. Shilova,
  • E. I. Kovalenko

摘要

Abstract

NK cells participate in the antimicrobial immune response. NK cell activation by bacterial polysaccharides (PSs) can occur indirectly through signals from other immune cells or through direct influence of PSs on NK cells via interaction with activating receptors. This study demonstrated that peripheral NK cells bind fluorescently labeled PSs from the Gram-negative bacteria Escherichia coli, Shigella flexneri, and Pseudomonas aeruginosa with varying efficiency depending on the PS origin and the NK cell donor. PSs from Escherichia coli strain O19ab induced an increased IFN-γ production by NK cells in the absence of high levels of PS binding to the cell surface. The obtained results provide new insights into the interactions of NK cells with polysaccharides and open new prospects for understanding the NK cell-mediated immune response to bacterial infections.