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Abstract <p>The serum of people with blood group O contains not only classical anti-A and anti-B, but also anti-A,B antibodies, i.e., those whose Fab region equally recognizes both the A and B blood group antigens. The common epitope of the A and B antigens, recognized by these antibodies, is located strictly on one side of the tetrasaccharide molecule, which was shown by studying their complex with anti-A,B antibodies using the Saturation Transfer Difference (STD NMR) spectroscopy.</p>

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Epitope Recognized by anti-A,B Antibodies of Blood Group O Individuals as Probed with STD NMR

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • S. V. Tsygankova,
  • P. S. Obukhova,
  • T. V. Tyrtysh,
  • A. S. Paramonov,
  • N. V. Bovin

摘要

Abstract

The serum of people with blood group O contains not only classical anti-A and anti-B, but also anti-A,B antibodies, i.e., those whose Fab region equally recognizes both the A and B blood group antigens. The common epitope of the A and B antigens, recognized by these antibodies, is located strictly on one side of the tetrasaccharide molecule, which was shown by studying their complex with anti-A,B antibodies using the Saturation Transfer Difference (STD NMR) spectroscopy.