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Abstract <p>The antibiofilm activity of two lectins from the hemolymph of the bivalve mollusk <i>Glycymeris yessoensis</i> (GYL and GYL-R) against opportunistic bacteria, Gram-positive <i>Staphylococcus aureus</i> and Gram-negative <i>Escherichia coli</i>, was studied for the first time. Lectins significantly suppressed the formation of biofilms of both <i>S. aureus</i> and <i>E. coli</i>. The most pronounced effect for GYL was demonstrated against <i>S. aureus</i>, and for GYL-R against <i>E. coli</i>, which is determined by the carbohydrate specificity of the antibacterial action of these lectins. In addition, GYL and GYL-R caused partial destruction of already formed biofilms by interacting with the exopolysaccharide matrix that forms the basis of bacterial biofilms.</p>

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Antibiofilm Activity of Hemolymph Lectins from the Bivalve Mollusk Glycymeris yessoensis

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • T. O. Mizgina,
  • I. V. Chikalovets,
  • O. I. Nedashkovskaya,
  • O. V. Chernikov

摘要

Abstract

The antibiofilm activity of two lectins from the hemolymph of the bivalve mollusk Glycymeris yessoensis (GYL and GYL-R) against opportunistic bacteria, Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, was studied for the first time. Lectins significantly suppressed the formation of biofilms of both S. aureus and E. coli. The most pronounced effect for GYL was demonstrated against S. aureus, and for GYL-R against E. coli, which is determined by the carbohydrate specificity of the antibacterial action of these lectins. In addition, GYL and GYL-R caused partial destruction of already formed biofilms by interacting with the exopolysaccharide matrix that forms the basis of bacterial biofilms.