Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles

期刊论文
发表日期：

2024年5月25日

查看全文

M. V. Filimonova,
D. D. Kolmanovich,
G. V. Tikhonowski,
D. S. Petrunya,
P. A. Kotelnikova,
A. A. Shitova,
O. V. Soldatova,
A. S. Filimonov,
V. A. Rybachuk,
A. O. Kosachenko,
K. A. Nikolaev,
G. A. Demyashkin,
A. A. Popov,
M. S. Savinov,
A. L. Popov,
I. V. Zelepukin,
A. A. Lipengolts,
K. E. Shpakova,
A. V. Kabashin,
S. N. Koryakin,
S. M. Deyev,
I. N. Zavestovskaya

摘要

Abstract

Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.