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Abstract <p>Transglutaminases (TGs) are a unique group of enzymes that facilitate the post-translational modification of proteins by forming isopeptide bonds. Understanding that diverse processes such as normal and cancerous cell growth, reproduction, and cell death rely on sufficient levels of transglutaminases and that these enzymes can influence the differentiation and proliferation of various cell types has led many researchers to explore these intriguing molecules. Additionally, transglutaminases play a role in several diseases, including celiac disease and neurological disorders. In mammals, nine distinct isoenzymes of TGs have been identified at the genomic level. However, only a limited number of proteins possess reliable structures for future studies, while most have only partial structures. We have predicted open and closed conformations of TG1, TG3, TG4, TG5, TG6, TG7 using AlphaFold and have calculated theoretical SAXS curves for each model using CRYSOL software. Moreover, we demonstrated the ability to distinguish open and closed conformation of TG1 using SAXS.</p>

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Saxs Curves Prediction for Human Transglutamin Ases

  • 期刊论文

  • 发表日期：

    2025年10月3日

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  • A. V. Alexandrova,
  • S. D. Ivashchenko,
  • A.V. Vlasov

摘要

Abstract

Transglutaminases (TGs) are a unique group of enzymes that facilitate the post-translational modification of proteins by forming isopeptide bonds. Understanding that diverse processes such as normal and cancerous cell growth, reproduction, and cell death rely on sufficient levels of transglutaminases and that these enzymes can influence the differentiation and proliferation of various cell types has led many researchers to explore these intriguing molecules. Additionally, transglutaminases play a role in several diseases, including celiac disease and neurological disorders. In mammals, nine distinct isoenzymes of TGs have been identified at the genomic level. However, only a limited number of proteins possess reliable structures for future studies, while most have only partial structures. We have predicted open and closed conformations of TG1, TG3, TG4, TG5, TG6, TG7 using AlphaFold and have calculated theoretical SAXS curves for each model using CRYSOL software. Moreover, we demonstrated the ability to distinguish open and closed conformation of TG1 using SAXS.