Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo

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发表日期：

2024年11月22日

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I. A. Zamulaeva,
O. N. Matchuk,
E. I. Selivanova,
V. A. Mosina,
M. R. Abramova,
V. O. Saburov,
S. N. Koryakin,
S. A. Ivanov,
A. D. Kaprin,
A. V. Boreyko,
V. N. Chausov,
E. A. Krasavin

摘要

Abstract

This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.