Repair Kinetics of DNA Double-Strand Breaks in Mammalian Cells under Photon Irradiation

This work aims at mathematically simulating the repair process of double-strand DNA breaks induced by rare ionizing radiation. A mathematical simulation of several stages of the cellular response to irradiation has been carried out: (i) Chinese hamster cells of the V79 line in the stationary phase of culture growth to the action of 250 keV X-ray irradiation and (ii) human carcinoma cells in the exponential phase of culture growth to \(\gamma \) -Co \(^{{60}}\) irradiation. The induction and repair of DNA double-strand breaks and the kinetics of formation of incorrectly repaired DNA double-strand breaks are studied. The simulation data are compared with experimental values.