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Abstract <p>The <i>S</i><sub>N</sub>Ar reaction of 4,5-dichlorophthalonitrile with various bifunctional nucleophiles was carried out in anhydrous DMF in the presence of K<sub>2</sub>CO<sub>3</sub> as a deprotonating agent. It was shown that 4,5-dichlorophthalonitrile can be successfully employed in the synthesis of heterocyclic compounds; however, in some cases, these reactions may either give product mixtures or result in an unexpected rearrangement.</p>

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Synthesis of Heterocycles Based on 4,5-Dichlorophthalonitrile

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • V. L. Baklagin,
  • V. V. Bukhalin,
  • I. G. Abramov,
  • V. V. Aleksandriiskii

摘要

Abstract

The SNAr reaction of 4,5-dichlorophthalonitrile with various bifunctional nucleophiles was carried out in anhydrous DMF in the presence of K2CO3 as a deprotonating agent. It was shown that 4,5-dichlorophthalonitrile can be successfully employed in the synthesis of heterocyclic compounds; however, in some cases, these reactions may either give product mixtures or result in an unexpected rearrangement.