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Abstract <p>A number of novel diaza- and triazaadamantane derivatives were synthesized by the reactions of 5,7-disubstituted 2-(4-aminophenyl)-1,3-diazaadamantanes, 1,3,5-triazaadamantane-7-amine, and (aminophenyl)(1,3,5-triazaadamantan-7-yl))methanones with anhydrides of substituted succinic and glutaric acids. Some of the synthesized compounds showed a moderate antibacterial activity against both Gram-positive and Gram-negative bacteria.</p>

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Synthesis of Novel Amino Derivatives of 1,3-Diaza- and 1,3,5-Triazadamantanes

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • K. A. Gevorkyan,
  • M. V. Galstyan,
  • M. V. Aleksanyan,
  • J. A. Avakimyan,
  • H. M. Stepanyan,
  • R. Y. Muradyan,
  • A. D. Harutyunyan

摘要

Abstract

A number of novel diaza- and triazaadamantane derivatives were synthesized by the reactions of 5,7-disubstituted 2-(4-aminophenyl)-1,3-diazaadamantanes, 1,3,5-triazaadamantane-7-amine, and (aminophenyl)(1,3,5-triazaadamantan-7-yl))methanones with anhydrides of substituted succinic and glutaric acids. Some of the synthesized compounds showed a moderate antibacterial activity against both Gram-positive and Gram-negative bacteria.