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Abstract <p>The multicomponent reaction of cyclohexanone, cyanothioacetamide, ethyl cyanoacetate or 3,5-di­methyl-1-(cyanoacetyl)-1<i>H</i>-pyrazole, and allyl bromide in ethanol or acetone in the presence of <i>N</i>-methyl­morpholine at 25°C afforded 2-(allylsulfanyl)-4-oxo-3-azaspiro[5.5]undec-1-ene-1,5-dicarbonitrile, whereas 1-allyl-4-oxo-2-sulfanylidene-3-azaspiro[5.5]undec-1-ene-1,5-dicarbonitrile was obtained under reflux condi­tions. The product structure was studied by spectral methods and X-ray analysis.</p>

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Multicomponent Synthesis of Allyl Derivatives of N-Methylmorpholinium 1,5-Dicyano-4-oxo-3-azaspiro[5.5]undec-1-ene-2-thiolate

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • A. V. Churakov,
  • B. S. Krivokolysko,
  • D. V. Nikitenko,
  • S. G. Krivokolysko

摘要

Abstract

The multicomponent reaction of cyclohexanone, cyanothioacetamide, ethyl cyanoacetate or 3,5-di­methyl-1-(cyanoacetyl)-1H-pyrazole, and allyl bromide in ethanol or acetone in the presence of N-methyl­morpholine at 25°C afforded 2-(allylsulfanyl)-4-oxo-3-azaspiro[5.5]undec-1-ene-1,5-dicarbonitrile, whereas 1-allyl-4-oxo-2-sulfanylidene-3-azaspiro[5.5]undec-1-ene-1,5-dicarbonitrile was obtained under reflux condi­tions. The product structure was studied by spectral methods and X-ray analysis.