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Abstract <p>A preparative method has been developed for the synthesis of 1,3,5-trinitro-2-(prop-2-yn-1-yloxy)benzene in 79% yield under mild conditions from commercially available initial compounds. The structure of the title compound has been confirmed by <sup>1</sup>H NMR spectroscopy. 1,3,5-Trinitro-2-(prop-2-yn-1-yloxy)benzene has been found to form noncovalent bioconjugates with DNA molecules and deoxynucleoside triphosphates. The resulting bioconjugates can be involved in click reactions with azide dyes.</p>

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Synthesis, Spectral Properties, and Noncovalent Bioconjugation of 1,3,5-Trinitro-2-(prop-2-yn-1-yloxy)benzene with Purine Nucleobases

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  • 出版模式：

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  • 发表日期：

    2025年12月1日

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  • D. A. Kazantsev,
  • M. V. Bytov,
  • O. S. Zaitseva

摘要

Abstract

A preparative method has been developed for the synthesis of 1,3,5-trinitro-2-(prop-2-yn-1-yloxy)benzene in 79% yield under mild conditions from commercially available initial compounds. The structure of the title compound has been confirmed by 1H NMR spectroscopy. 1,3,5-Trinitro-2-(prop-2-yn-1-yloxy)benzene has been found to form noncovalent bioconjugates with DNA molecules and deoxynucleoside triphosphates. The resulting bioconjugates can be involved in click reactions with azide dyes.