Abstract <p>α-Aminophosphonates are of considerable interest due to their potential pharmacological properties. The Kabachnik–Fields reaction, a one-pot, three-component condensation, is a prevalent method for the synthesis of α-aminophosphonates. Microwave irradiation has emerged as a popular technique owing to its efficiency, versatility, and environmentally benign nature, and has been successfully applied to the Kabachnik–Fields reaction. This approach offers significant advantages, including reduced reaction times, higher yields, and improved product purity. The present review provides a comprehensive overview of the synthesis of α-aminophosphonate derivatives via the Kabachnik–Fields reaction under microwave irradiation as a versatile, efficient, and green methodology. Various synthetic protocols and reaction conditions are discussed, encompassing the use of different catalysts, solvents, and starting materials, along with the diverse biological activities exhibited by the resulting α-aminophosphonates.</p>