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Abstract <p>The Ritter reaction of 2-(2-methoxyphenyl)-1-methylcyclohexan-1-ols with various nitriles was investigated. Depending on the nature of the nitrile and the substituents on the 2-methoxyphenyl fragment of the alcohols, the reaction can lead to both <i>N</i>-2-(2-methoxyphenyl)-1-methylcyclohexyl)amides and derivatives of partially hydrogenated spiroindolenines in a diastereoselective manner.</p>

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2-(2-Methoxyphenyl)-1-methylcyclohexan-1-ols in the Ritter Reaction

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Y. S. Rozhkova,
  • A. S. Pegushina,
  • O. A. Mayorova,
  • V. V. Morozov,
  • Y. V. Shklyaev

摘要

Abstract

The Ritter reaction of 2-(2-methoxyphenyl)-1-methylcyclohexan-1-ols with various nitriles was investigated. Depending on the nature of the nitrile and the substituents on the 2-methoxyphenyl fragment of the alcohols, the reaction can lead to both N-2-(2-methoxyphenyl)-1-methylcyclohexyl)amides and derivatives of partially hydrogenated spiroindolenines in a diastereoselective manner.