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Abstract <p>A novel and sustainable method for synthesizing pyranopyrazole derivatives is introduced, utilizing theophylline as a catalyst in a solvent-free process at ambient temperature. This one-pot multicomponent reaction (MCR) effectively combines aromatic or heteroaromatic aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate to produce the desired compounds in high yields. Key advantages of this protocol include its eco-friendly nature, clean reaction profile, minimal reaction time, and simplified workup procedure. The approach also demonstrates excellent atom economy, contributing to reduced waste generation and enhanced process sustainability.</p>

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Efficient and Environmentally Benign One-Pot Multicomponent Synthesis of Pyranopyrazole Derivatives Using Theophylline as a Recyclable Catalyst

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Mayuri B. Thorat,
  • Aniket N. Timble,
  • Yatin U. Gadkari

摘要

Abstract

A novel and sustainable method for synthesizing pyranopyrazole derivatives is introduced, utilizing theophylline as a catalyst in a solvent-free process at ambient temperature. This one-pot multicomponent reaction (MCR) effectively combines aromatic or heteroaromatic aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate to produce the desired compounds in high yields. Key advantages of this protocol include its eco-friendly nature, clean reaction profile, minimal reaction time, and simplified workup procedure. The approach also demonstrates excellent atom economy, contributing to reduced waste generation and enhanced process sustainability.