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Abstract <p>A convenient and an accessible method for the synthesis of novel heterocyclic hybrid systems—3-[2-(1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)ethyl)-4-methylquinolin-2(1<i>H</i>)-ones, 3-(2-(benzo[<i>d</i>]oxazol-2-yl)ethyl)-4-methylquinolin-2(1<i>H</i>)-ones, and 3-(2-(benzo[<i>d</i>]thiazol-2-yl)ethyl)-4-methylquinolin-2(1<i>H</i>)-ones—was developed. The synthesis was carried out by reacting ethyl 3-(4-methyl-2-oxo-1,2-dihydroquinolin-3-yl)propanoates, substituted in the benzene ring, with <i>o</i>-phenylenediamine, <i>o</i>-aminophenol, and <i>o</i>-aminobenzenethiol.</p>

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Synthesis of Quinoline Derivatives of Ethyl 3-(4-Methyl-2-oxo-1,2-dihydroquinoline-3-yl)propanoates

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • I. L. Aleksanyan,
  • L. P. Hambardzumyan

摘要

Abstract

A convenient and an accessible method for the synthesis of novel heterocyclic hybrid systems—3-[2-(1H-benzo[d]imidazol-2-yl)ethyl)-4-methylquinolin-2(1H)-ones, 3-(2-(benzo[d]oxazol-2-yl)ethyl)-4-methylquinolin-2(1H)-ones, and 3-(2-(benzo[d]thiazol-2-yl)ethyl)-4-methylquinolin-2(1H)-ones—was developed. The synthesis was carried out by reacting ethyl 3-(4-methyl-2-oxo-1,2-dihydroquinolin-3-yl)propanoates, substituted in the benzene ring, with o-phenylenediamine, o-aminophenol, and o-aminobenzenethiol.