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Abstract <p>A new synthesis of 2,5-di(het)aryl-1,3,4-thiadiazoles via the iodine-mediated reaction between easily available benzothiohydrazides and aldehydes has been accomplished. All the final products were characterized IR, NMR, and HRMS. A mechanism of the reaction has been proposed. Short reaction time, good to high product yields, and the use of easily available, inexpensive starting materials are the key features of this protocol.</p>

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Oxidative Cyclization as a Novel Method for the Synthesis of 2,5-Disubstituted 1,3,4-Thiadiazoles from Benzothiohydrazides and Aldehydes

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • K. Mahesha,
  • B. Lakshmana,
  • M. R. Malliyappa,
  • J. Manasa,
  • Y. B. Basavaraju

摘要

Abstract

A new synthesis of 2,5-di(het)aryl-1,3,4-thiadiazoles via the iodine-mediated reaction between easily available benzothiohydrazides and aldehydes has been accomplished. All the final products were characterized IR, NMR, and HRMS. A mechanism of the reaction has been proposed. Short reaction time, good to high product yields, and the use of easily available, inexpensive starting materials are the key features of this protocol.