Scholarlink

Abstract <p>A series of novel 2-aminothiazole–1,2,3-triazole hybrid compounds were synthesized using a click chemistry strategy, specifically by coupling substituted <i>N</i>-(4-aryl-1,3-thiazol-2-yl)-2-azidoacetamides with terminal alkynes. The structures of the resulting compounds were confirmed through spectroscopic methods, including <sup>1</sup>H and <sup>13</sup>C NMR, mass spectrometry, infrared spectroscopy, and elemental analysis. The anticancer efficacy of compounds <b>5a</b>–<b>5j</b> was assessed against a panel of 60 human cancer cell lines, following the NIH screening protocol. Among the tested compounds, <b>5a</b>, <b>5b</b>, <b>5f</b>, <b>5g</b>, <b>5h</b>, and <b>5j</b> exhibited significant inhibitory activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and Anticancer Activity of Novel 1,2,3-Triazole-Linked Thiazole Derivatives

  • 期刊论文

  • 发表日期：

    2026年2月1日

查看全文
  • V. V. Jadvani,
  • Y. T. Naliapara

摘要

Abstract

A series of novel 2-aminothiazole–1,2,3-triazole hybrid compounds were synthesized using a click chemistry strategy, specifically by coupling substituted N-(4-aryl-1,3-thiazol-2-yl)-2-azidoacetamides with terminal alkynes. The structures of the resulting compounds were confirmed through spectroscopic methods, including 1H and 13C NMR, mass spectrometry, infrared spectroscopy, and elemental analysis. The anticancer efficacy of compounds 5a–5j was assessed against a panel of 60 human cancer cell lines, following the NIH screening protocol. Among the tested compounds, 5a, 5b, 5f, 5g, 5h, and 5j exhibited significant inhibitory activity.