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Abstract <p>Multicomponent reaction of 4-nitrobenzaldehyde, cyanothioacetamide, <i>N</i>-(2-methylphenyl)-3-oxo­butanamide, and alkyl halides in boiling ethanol in the presence of 2 equiv of potassium hydroxide afforded 5-cyano-2-methyl-<i>N</i>-(2-methylphenyl)-4-(4-nitrophenyl)-6-sulfanylidene-1,6-dihydropyridine-3-carboxamide derivatives such as 2-(alkylsulfanyl)pyridines and 3-aminothieno[2,3-<i>b</i>]pyridines in 64–91% yields.</p>

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Synthesis of 5-Cyano-2-methyl-N-(2-methylphenyl)-4-(4-nitrophenyl)-6-sulfanylidene-1,6-dihydropyridine-3-carboxamide Derivatives

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • B. S. Krivokolysko,
  • D. V. Nikitenko,
  • S. G. Krivokolysko

摘要

Abstract

Multicomponent reaction of 4-nitrobenzaldehyde, cyanothioacetamide, N-(2-methylphenyl)-3-oxo­butanamide, and alkyl halides in boiling ethanol in the presence of 2 equiv of potassium hydroxide afforded 5-cyano-2-methyl-N-(2-methylphenyl)-4-(4-nitrophenyl)-6-sulfanylidene-1,6-dihydropyridine-3-carboxamide derivatives such as 2-(alkylsulfanyl)pyridines and 3-aminothieno[2,3-b]pyridines in 64–91% yields.