Scholarlink

Abstract <p>Pyrazole and its derivatives are fascinating heterocyclic compounds because of their significant biomedical applications, including anticancer, antimalarial, antimicrobial, antifungal, and antitubercular properties. Pyrazole ring is a recognized structure found in many pharmacologically active substances. In this study, the synthesis of (<i>E</i>)-4-(benzylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3<i>H</i>-pyrazol-3-one deriva­tives <b>7a</b>–<b>7j</b> was accomplished through a multistep procedure. The process involves the condensation and cyclization of 1-methyl-2-phenylhydrazine with ethyl 3-oxobutanoate, followed by nitration, reduction, and subsequent reaction with substituted benzaldehydes. The synthesis was optimized by exploring the effects of the solvent ratio and reaction time on the yield of <b>7a</b>. The synthesized compounds were characterized based on their spectral data (IR, <sup>1</sup>H and <sup>13</sup>C NMR, and mass spectra). The antimicrobial activities of all synthesized compounds were evaluated against four bacterial strains (<i>S. aureus</i> MTCC 2408, <i>B. cereus</i> MTCC 430, <i>E. coli</i> MTCC 2412, and <i>P. aeruginosa</i> MTCC 2081) and two fungal strains (<i>C. albicans</i> MTCC 227, and <i>C. tropicalis</i> MTCC 230).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and Biological Evaluation of Pyrazole-Based Schiff Bases as Antibacterial and Antifungal Agents

  • 期刊论文

  • 发表日期：

    2026年2月1日

查看全文
  • P. Joshi,
  • G. Sanghavi,
  • S. Thakrar

摘要

Abstract

Pyrazole and its derivatives are fascinating heterocyclic compounds because of their significant biomedical applications, including anticancer, antimalarial, antimicrobial, antifungal, and antitubercular properties. Pyrazole ring is a recognized structure found in many pharmacologically active substances. In this study, the synthesis of (E)-4-(benzylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one deriva­tives 7a–7j was accomplished through a multistep procedure. The process involves the condensation and cyclization of 1-methyl-2-phenylhydrazine with ethyl 3-oxobutanoate, followed by nitration, reduction, and subsequent reaction with substituted benzaldehydes. The synthesis was optimized by exploring the effects of the solvent ratio and reaction time on the yield of 7a. The synthesized compounds were characterized based on their spectral data (IR, 1H and 13C NMR, and mass spectra). The antimicrobial activities of all synthesized compounds were evaluated against four bacterial strains (S. aureus MTCC 2408, B. cereus MTCC 430, E. coli MTCC 2412, and P. aeruginosa MTCC 2081) and two fungal strains (C. albicans MTCC 227, and C. tropicalis MTCC 230).