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Abstract <p>Heart failure (HF) remains a critical global health challenge, characterized by high morbidity and mortality rates. Current therapeutic options are limited, and there is a pressing need to develop novel, safe, and effective drugs. Natural products, with their inherent multi-target activities and favorable toxicity profiles, represent a promising source for new HF therapies. This review summarizes the structural classes of natural products demonstrating potential anti-heart failure efficacy, including flavonoids (e.g., puerarin, quercetin), saponins (e.g., ginsenoside Rb1, astragaloside IV), phenolic acids (e.g., resveratrol, curcumin), polysaccharides, terpenoids, alkaloids, and quinones. The discussed compounds are known to improve cardiac function and mitigate HF progression through diverse mechanisms, such as antioxidative and anti-inflammatory actions, regulation of autophagy and apoptosis, and enhancement of mitochondrial function. Further investigation into these natural compounds is essential to fully realize their therapeutic potential against HF.</p>

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Unlocking the Therapeutic Potential of Natural Products for Heart Failure

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • Ya-Jing Zhou,
  • Zhang-Xu He,
  • Jian Song,
  • Yuanbing Du,
  • Sasa Jin,
  • Guangxu Zhang,
  • Yuman Li,
  • Anwei Liu,
  • Feifei Yang,
  • Ziqiao Yuan,
  • Jingyu Zhang

摘要

Abstract

Heart failure (HF) remains a critical global health challenge, characterized by high morbidity and mortality rates. Current therapeutic options are limited, and there is a pressing need to develop novel, safe, and effective drugs. Natural products, with their inherent multi-target activities and favorable toxicity profiles, represent a promising source for new HF therapies. This review summarizes the structural classes of natural products demonstrating potential anti-heart failure efficacy, including flavonoids (e.g., puerarin, quercetin), saponins (e.g., ginsenoside Rb1, astragaloside IV), phenolic acids (e.g., resveratrol, curcumin), polysaccharides, terpenoids, alkaloids, and quinones. The discussed compounds are known to improve cardiac function and mitigate HF progression through diverse mechanisms, such as antioxidative and anti-inflammatory actions, regulation of autophagy and apoptosis, and enhancement of mitochondrial function. Further investigation into these natural compounds is essential to fully realize their therapeutic potential against HF.