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Abstract <p>4-Methyl- and 4-amino-1,2,5-oxadiazole-3-carbohydrazonamides reacted with glyoxal to give the corresponding dimeric products, <i>N</i>′,<i>N</i>″-(ethane-1,2-diylidene)bis(4-R-1,2,5-oxadiazole-3-carbohydrazonamides) (R = Me, NH<sub>2</sub>), whereas the reaction of the same substrates with other 1,2-dicarbonyl compounds, such as benzil and ninhydrin afforded target 3-(4-R-1,2,5-oxadiazol-3-yl)-1,2,4-triazine derivatives. The product structure was confirmed by IR and NMR spectra and X-ray analysis. The synthesized compounds are promising as scaffolds for the design of pharmacologically active compounds with different kinds of activity.</p>

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Synthesis of (1,2,4-Triazinyl)furazans

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • A. A. Larin,
  • A. V. Shaferov,
  • I. V. Ananyev,
  • L. L. Fershtat

摘要

Abstract

4-Methyl- and 4-amino-1,2,5-oxadiazole-3-carbohydrazonamides reacted with glyoxal to give the corresponding dimeric products, N′,N″-(ethane-1,2-diylidene)bis(4-R-1,2,5-oxadiazole-3-carbohydrazonamides) (R = Me, NH2), whereas the reaction of the same substrates with other 1,2-dicarbonyl compounds, such as benzil and ninhydrin afforded target 3-(4-R-1,2,5-oxadiazol-3-yl)-1,2,4-triazine derivatives. The product structure was confirmed by IR and NMR spectra and X-ray analysis. The synthesized compounds are promising as scaffolds for the design of pharmacologically active compounds with different kinds of activity.