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Abstract <p>The study of 5,7-dihydroxycoumarins as nucleophilic agents in the S<sub>N</sub><sup>H</sup> reaction with pyrimidines showed that the reaction does not stop at the stage of formation of σ<sup>H</sup>-adduct as intermediate in the S<sub>N</sub><sup>H</sup> mechanism but proceeds further with annulation of the 1,3,5-oxadiazocine ring in moderate to excellent yields. The structures of the obtained compounds were confirmed by NMR spectroscopy and X-ray diffraction. A primary in vitro assessment of their antitumor activity was performed.</p>

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Reaction of 5,7-Dihydroxycoumarins with Pyrimidines

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • R. F. Fatykhov,
  • I. A. Khalymbadzha,
  • A. P. Potapova,
  • V. V. Melekhin,
  • A.V. Paramonova,
  • D. S. Kopchuk,
  • P. A. Slepukhin,
  • V. G. Kartsev,
  • O. N. Chupakhin

摘要

Abstract

The study of 5,7-dihydroxycoumarins as nucleophilic agents in the SNH reaction with pyrimidines showed that the reaction does not stop at the stage of formation of σH-adduct as intermediate in the SNH mechanism but proceeds further with annulation of the 1,3,5-oxadiazocine ring in moderate to excellent yields. The structures of the obtained compounds were confirmed by NMR spectroscopy and X-ray diffraction. A primary in vitro assessment of their antitumor activity was performed.