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Abstract <p>Eugenol, a natural product with diverse biological activities, exhibits significant potential as a lead compound for clinical drug development. In this study, we designed and successfully synthesized six novel 1,3,4-thiadiazole eugenol derivatives and evaluated their antibacterial activity. Two of the synthesized compounds exhibited moderate antibacterial activity against Staphylococcus aureus, displaying minimum inhibitory concentrations (MICs) that were equal to or lower than the MIC of gentamicin (16 and 32 µg/mL vs. 32 µg/mL, respectively). These findings suggest that further structural optimization and mechanistic studies are warranted to enhance the antibacterial potency of the synthesized eugenol derivatives.</p>

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Synthesis of Novel 1,3,4-Thiadiazole Eugenol Derivatives and Evaluation of Their Activity against Staphylococcus aureus

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Gang Wei,
  • Meishan Li,
  • Pengcheng Wei,
  • Canmei Huang,
  • Silin Pan,
  • Haiying Luo,
  • Yuban Lei,
  • Yi Wei,
  • Jiazi Luo

摘要

Abstract

Eugenol, a natural product with diverse biological activities, exhibits significant potential as a lead compound for clinical drug development. In this study, we designed and successfully synthesized six novel 1,3,4-thiadiazole eugenol derivatives and evaluated their antibacterial activity. Two of the synthesized compounds exhibited moderate antibacterial activity against Staphylococcus aureus, displaying minimum inhibitory concentrations (MICs) that were equal to or lower than the MIC of gentamicin (16 and 32 µg/mL vs. 32 µg/mL, respectively). These findings suggest that further structural optimization and mechanistic studies are warranted to enhance the antibacterial potency of the synthesized eugenol derivatives.