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Abstract <p>A green sustainable one-pot multicomponent condensation of aldehydes, isatoic anhydride, and ammonium acetate in refluxing ethanol has been developed for the synthesis of 2,3-dihydroquinazolin-4(1<i>H</i>)-ones using copper, zinc sulfide, or nickel sulfide-loaded carbon-based heterogeneous catalysts prepared from metal salt-loaded sulfonate-functionalized styrene–divinylbenzene copolymers. The developed protocol is efficient, convenient, and superior to the existing methods for the synthesis of dihydroquinazolin-4(1<i>H</i>)-ones. High yields, environmentally benign conditions, simple work-up, and catalyst reusability without a significant loss in catalytic efficiency are the main advantages of this protocol.</p>

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A Green and Sustainable Access to 2,3-Dihydroquinazolin-4(1H)-ones Using Nanosized Heterogeneous Metal/Metal Sulfide@Carbon Catalyst

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • A. D. Tangade,
  • A. V. Dhirbassi,
  • S. S. Kauthale,
  • L. Kótai,
  • R. P. Pawar,
  • S. U. Tekale

摘要

Abstract

A green sustainable one-pot multicomponent condensation of aldehydes, isatoic anhydride, and ammonium acetate in refluxing ethanol has been developed for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using copper, zinc sulfide, or nickel sulfide-loaded carbon-based heterogeneous catalysts prepared from metal salt-loaded sulfonate-functionalized styrene–divinylbenzene copolymers. The developed protocol is efficient, convenient, and superior to the existing methods for the synthesis of dihydroquinazolin-4(1H)-ones. High yields, environmentally benign conditions, simple work-up, and catalyst reusability without a significant loss in catalytic efficiency are the main advantages of this protocol.