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Abstract <p>An effective synthesis of optically pure macrocyclic polylactones is developed, involving the [1+1] condensation of a natural triol (castor oil) with thionyl chloride in carbon tetrachloride in the presence of DMF as a base and (<i>N</i>,<i>N</i>-dimethylamino)pyridine as a catalyst and followed by the [1+1] condensation of the resulting macrocyclic alcohol with sebacoyl chloride under similar conditions.</p>

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Efficient Synthesis of Optically Pure Macrocyclic Polylactones from Castor Oil and Sulfurous and Sebacic Acid Dichlorides

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • M. P. Yakovleva,
  • I. S. Nazarov,
  • K. M. Saitov,
  • G. Y. Ishmuratov,
  • A. G. Tolstikov

摘要

Abstract

An effective synthesis of optically pure macrocyclic polylactones is developed, involving the [1+1] condensation of a natural triol (castor oil) with thionyl chloride in carbon tetrachloride in the presence of DMF as a base and (N,N-dimethylamino)pyridine as a catalyst and followed by the [1+1] condensation of the resulting macrocyclic alcohol with sebacoyl chloride under similar conditions.