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Abstract <p>The novel bioactive compound 5-amino-3-[(1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)methyl]-1,3,4-thiadiazole-2(3<i>H</i>)-thione was synthesized using 5-amino-1,3,4-thiadiazole-2-thiol and benzimidazole as key precursors. The product was comprehensively characterized by IR and NMR (<sup>1</sup>H and <sup>13</sup>C) spectroscopy and mass spectrometry. Antibacterial screening against <i>Staphylococcus aureus</i> (Gram-positive) and <i>Escherichia coli</i> (Gram-negative) bacteria, as well as the anti-inflammatory assay revealed promising activities of the synthesized benzimidazole–1,3,4-thiadiazole hybrid product, underscoring its potential therapeutic applications.</p>

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5-Amino-3-[(1H-benzo[d]imidazol-1-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione: Synthesis, Biological Evaluation, Molecular Docking, and ADME Analysis

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • S. Parab,
  • W. Shah,
  • S. Gadakh,
  • P. Shinde,
  • S. Janwadkar,
  • D. Yadav

摘要

Abstract

The novel bioactive compound 5-amino-3-[(1H-benzo[d]imidazol-1-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione was synthesized using 5-amino-1,3,4-thiadiazole-2-thiol and benzimidazole as key precursors. The product was comprehensively characterized by IR and NMR (1H and 13C) spectroscopy and mass spectrometry. Antibacterial screening against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) bacteria, as well as the anti-inflammatory assay revealed promising activities of the synthesized benzimidazole–1,3,4-thiadiazole hybrid product, underscoring its potential therapeutic applications.