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Abstract <p>New quinoline–benzimidazole hybrids <b>3a</b>–<b>3d</b> have been synthesized from 1-(quinolin-5-yl)­ethanone and benzene-1,2-diamine and converted to the corresponding <i>N</i>-tosyl (<b>4a</b>–<b>4d</b>) and <i>N</i>-methyl derivatives (<b>5a</b>–<b>5d</b>). The synthesized compounds were characterized by IR, NMR, and mass spectra. Compounds <b>4a</b> and <b>4c</b> demonstrated exceptional anticancer efficacy against HeLa cell line. Compounds <b>4a</b> and <b>4d</b>, however, were more active against HT-29 cell line.</p>

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Synthesis and Anticancer Activity of Quinoline–Benzimidazole Hybrids

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • Ch. Sunitha,
  • S. Shamili,
  • P. Somalaxmi

摘要

Abstract

New quinoline–benzimidazole hybrids 3a–3d have been synthesized from 1-(quinolin-5-yl)­ethanone and benzene-1,2-diamine and converted to the corresponding N-tosyl (4a–4d) and N-methyl derivatives (5a–5d). The synthesized compounds were characterized by IR, NMR, and mass spectra. Compounds 4a and 4c demonstrated exceptional anticancer efficacy against HeLa cell line. Compounds 4a and 4d, however, were more active against HT-29 cell line.