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Abstract <p>A novel and efficient method for synthesizing substituted β-trifluoromethyl styrenes through a copper-catalyzed desulfitative trifluoromethylation reaction was developed. This innovative approach utilizes 2-phenylethenesulfinic acid as a substrate and sodium trifluoromethanesulfinate as a CF<sub>3</sub> source under relatively mild reaction conditions. Notably, this protocol demonstrates remarkable stereoselectivity and wide substrate compatibility, offering a versatile platform for the preparation of β-trifluoromethyl styrene derivatives.</p>

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Cu-Catalyzed Desulfitative Trifluoromethylation of Styrene Sulfinic Acid with CF3SO2Na

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • J. Song,
  • J. Shao,
  • Sh. He,
  • M. Wei,
  • D. Chen,
  • J. Liu

摘要

Abstract

A novel and efficient method for synthesizing substituted β-trifluoromethyl styrenes through a copper-catalyzed desulfitative trifluoromethylation reaction was developed. This innovative approach utilizes 2-phenylethenesulfinic acid as a substrate and sodium trifluoromethanesulfinate as a CF3 source under relatively mild reaction conditions. Notably, this protocol demonstrates remarkable stereoselectivity and wide substrate compatibility, offering a versatile platform for the preparation of β-trifluoromethyl styrene derivatives.