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Abstract <p>4-(2-Aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydro-1<i>H</i>-pyrrol-1-yl)benzoic acids were synthesized by three-component condensation of methyl aroylpyruvates, aromatic aldehydes, and 4-aminobenzoic acid (PABA) in glacial acetic acid. Their structure was confirmed by <sup>1</sup>H and <sup>13</sup>C NMR and IR spectra, as well as by X-ray analysis, and their analgesic and anti-inflammatory activity was studied.</p>

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Synthesis and Analgesic and Anti-inflammatory Activity of 4-(2-Aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic Acids

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • V. L. Gein,
  • D. V. Chalkov,
  • A. V. Romanova,
  • O. V. Bobrovskaya,
  • S. V. Chashchina,
  • M. V. Dmitriev

摘要

Abstract

4-(2-Aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acids were synthesized by three-component condensation of methyl aroylpyruvates, aromatic aldehydes, and 4-aminobenzoic acid (PABA) in glacial acetic acid. Their structure was confirmed by 1H and 13C NMR and IR spectra, as well as by X-ray analysis, and their analgesic and anti-inflammatory activity was studied.