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Abstract <p>Using 2,2′-methylenedi(cyclohexan-1-one) as an example of alicyclic 1,5-diketones, selective preparative methods for the transformation of its racemic form into diastereomeric tetracyclic ozonides by the action of 30% hydrogen peroxide in acid medium have been demonstrated, and a plausible mechanism of stereoisomeric transformations has been proposed. Tetracyclic dispiro ozonides may be promising lead compounds for the design of therapeutic agents for the treatment of drug-resistant prostate cancer.</p>

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Stereoisomerism and Anticancer Activity of Tetracyclic Dispiro Ozonides (1,2,4-Trioxolanes) Obtained by the Reaction of Alicyclic 1,5-Diketones with Hydrogen Peroxide

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • T. I. Akimova,
  • O. A. Soldatkina,
  • V. G. Savchenko,
  • N. Nekbin,
  • A. V. Pilipenko,
  • I. V. Svistunova,
  • S. A. Dyshlovoy

摘要

Abstract

Using 2,2′-methylenedi(cyclohexan-1-one) as an example of alicyclic 1,5-diketones, selective preparative methods for the transformation of its racemic form into diastereomeric tetracyclic ozonides by the action of 30% hydrogen peroxide in acid medium have been demonstrated, and a plausible mechanism of stereoisomeric transformations has been proposed. Tetracyclic dispiro ozonides may be promising lead compounds for the design of therapeutic agents for the treatment of drug-resistant prostate cancer.