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Abstract <p>With the goal of searching for new more chemically stable analogues (prodrugs), isomeric misoprostol (9E/Z)-oximes and individual 11α-acetoxy (9E)-O-acetyloxime derivative have been synthesized and characterized. The ratio of the E and Z oximes has been estimated at 10:1 on the basis of the oxime OH signal intensities in the <sup>1</sup>H NMR spectrum.</p>

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Misoprostol (9E)-Oxime

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • N. K. Selezneva,
  • V. V. Zagitov,
  • N. S. Vostrikov,
  • A. M. Gimazetdinov,
  • M. S. Miftakhov

摘要

Abstract

With the goal of searching for new more chemically stable analogues (prodrugs), isomeric misoprostol (9E/Z)-oximes and individual 11α-acetoxy (9E)-O-acetyloxime derivative have been synthesized and characterized. The ratio of the E and Z oximes has been estimated at 10:1 on the basis of the oxime OH signal intensities in the 1H NMR spectrum.