Scholarlink

Abstract <p>The title compounds were synthesized through the reaction of the corresponding (<i>E</i>)-3-aryl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-ones with phenylhydrazine in glacial acetic acid. Their structure was confirmed by elemental analysis, infrared spectroscopy, <sup>1</sup>H and <sup>13</sup>C NMR, and mass spectrometry The new pyrazole derivatives were evaluated for their antibacterial activity against a range of microbial species, including <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i> (Gram-negative), <i>Staphylococcus aureus</i>, <i>Bacillus subtilis</i> (Gram-positive), and <i>Candida albicans</i>. The synthesized compounds also demonstrated superior in vitro anticancer activity compared to doxorubicin.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

4-Aryl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazoles: Synthesis, Characterization, and Biological Activity

  • 期刊论文

  • 发表日期：

    2025年4月1日

查看全文
  • P. A. Rechel,
  • S. Erukala,
  • S. Jyothi

摘要

Abstract

The title compounds were synthesized through the reaction of the corresponding (E)-3-aryl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-ones with phenylhydrazine in glacial acetic acid. Their structure was confirmed by elemental analysis, infrared spectroscopy, 1H and 13C NMR, and mass spectrometry The new pyrazole derivatives were evaluated for their antibacterial activity against a range of microbial species, including Escherichia coli, Pseudomonas aeruginosa (Gram-negative), Staphylococcus aureus, Bacillus subtilis (Gram-positive), and Candida albicans. The synthesized compounds also demonstrated superior in vitro anticancer activity compared to doxorubicin.