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Abstract <p>Chiral 1,2-diphenylethylenediamine (DPEN) was introduced into isosteviol-derived thiourea organo­catalyst to promote the Michael addition of aromatic ketones and nitroalkenes. Under neutral conditions, the new isosteviol-DPEN thiourea catalyst provides high yield (up to 98%) and enantioselectivity (up to 97%) of the Michael addition products with dual stereoselective control. Furthermore, the isosteviol-DPEN thiourea catalyst showed sufficient recyclability and maintained the stereoselectivity in five reuse cycles.</p>

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Development of Isosteviol-Based Bifunctional Thiourea Organocatalysts for Michael Addition of Aromatic Ketones and Nitroalkenes

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • Yuxia Liu,
  • Zhaoyang Fan,
  • Qi Liu,
  • Mingyang Lv,
  • Xinyu Dai

摘要

Abstract

Chiral 1,2-diphenylethylenediamine (DPEN) was introduced into isosteviol-derived thiourea organo­catalyst to promote the Michael addition of aromatic ketones and nitroalkenes. Under neutral conditions, the new isosteviol-DPEN thiourea catalyst provides high yield (up to 98%) and enantioselectivity (up to 97%) of the Michael addition products with dual stereoselective control. Furthermore, the isosteviol-DPEN thiourea catalyst showed sufficient recyclability and maintained the stereoselectivity in five reuse cycles.