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Abstract <p>An operationally simple, one-pot multicomponent protocol has been developed for the assembly of polysubstituted pyrans via an atom-economic transformation incorporating benzaldehyde, 4-hydroxycoumarin (dimedone, or cyclohexane-1,3-dione), and benzoylacetonitriles. This process involves L-proline-catalyzed domino condensation and Michael addition. The reaction is carried out by simply mixing the reactants and the catalyst in ethanol, followed by heating at 70°C, and the products are isolated in good yields after convenient workup.</p>

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L-Proline as a Catalyst for the Synthesis of Polysubstituted Pyran Derivatives via Multicomponent Reaction

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • Mugada Sugunakara Rao,
  • M. Ravi Chandra,
  • T. V. S. P. V. Satya Guru

摘要

Abstract

An operationally simple, one-pot multicomponent protocol has been developed for the assembly of polysubstituted pyrans via an atom-economic transformation incorporating benzaldehyde, 4-hydroxycoumarin (dimedone, or cyclohexane-1,3-dione), and benzoylacetonitriles. This process involves L-proline-catalyzed domino condensation and Michael addition. The reaction is carried out by simply mixing the reactants and the catalyst in ethanol, followed by heating at 70°C, and the products are isolated in good yields after convenient workup.