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Abstract <p>A novel series of 3,3-dimethyltriazene-bearing chalcone epoxides and 2-thioxo-tetrahydropyrimidine-5(2<i>H</i>)-one derivatives have been designed and synthesized. The synthesized compounds were characterized by IR and <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, mass spectrometry, and elemental analysis and screened in vitro against MCF-7 breast cancer cell lines by the MTS assay with Tamoxifen as a reference drug. Out of the fourteen tested compounds, ten demonstrated a significant anticancer potential against MCF-7 carcinoma cells.</p>

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Synthesis and Evaluation of Novel Dimethyltriazene Epoxide and 2-Thioxotetrahydropyrimidin-5(2H)-one Derivatives as Potential Anticancer Agents

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Vidhya V. Jadvani,
  • Yogesh T. Naliapara

摘要

Abstract

A novel series of 3,3-dimethyltriazene-bearing chalcone epoxides and 2-thioxo-tetrahydropyrimidine-5(2H)-one derivatives have been designed and synthesized. The synthesized compounds were characterized by IR and 1H and 13C NMR spectroscopy, mass spectrometry, and elemental analysis and screened in vitro against MCF-7 breast cancer cell lines by the MTS assay with Tamoxifen as a reference drug. Out of the fourteen tested compounds, ten demonstrated a significant anticancer potential against MCF-7 carcinoma cells.