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Abstract <p>Cashew shell extract has been found to be a natural acid catalyst, leading to the development of a straightforward, easy, and environmentally friendly Biginelli synthesis of dihydropyrimidinone/thione derivatives. The Biginelli reaction was conducted in a single step under microwave irradiation and provided outstanding yields in a shorter reaction time. The proposed method may be utilized to create dihydro­pyrimidinone/thione derivatives on a wide scale due to simple reaction conditions and low cost and availability of the catalyst.</p>

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Microwave-Assisted Efficient and Green Synthesis of Dihydropyrimidinone(thione) Derivatives via Biginelli Reaction Using Cashew Shell Extract as Natural Acid Catalyst

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • S. B. Manjare,
  • R. G. Thorat,
  • S. S. Dalvi,
  • K. S. Manval,
  • P. P. More,
  • R. K. Mahadik

摘要

Abstract

Cashew shell extract has been found to be a natural acid catalyst, leading to the development of a straightforward, easy, and environmentally friendly Biginelli synthesis of dihydropyrimidinone/thione derivatives. The Biginelli reaction was conducted in a single step under microwave irradiation and provided outstanding yields in a shorter reaction time. The proposed method may be utilized to create dihydro­pyrimidinone/thione derivatives on a wide scale due to simple reaction conditions and low cost and availability of the catalyst.