Synthesis, Characterization, and Pharmacokinetic Studies of Novel HydroquinoneBased 1,2,3-Triazole/Amide Derivatives as Anticancer and Antibacterial Agents

In the present study, new hydroquinone-based 1,2,3-triazole/amide analogues have been prepared and tested for anticancer and antibacterial potential. The structures of final derivatives were established using various analytical techniques. Compound 8, containing para-bromo-1,2,3-triazole nucleus, showed promising cytotoxicity with IC₅₀ of 0.92, 1.72, and 3.56 μM towards MCF-7, HepG2 and SKOV3 cells, respectively, comparable to standard drug doxorubicin. A chloro-bearing hydroquinone derivative (6) exhibited the highest antibacterial potential against S. aureus (MIC 25 μg/mL) and E.coli (MIC 50 μg/mL), which were equipotent to amoxicillin. In terms of in silico ADME properties, all the derivatives followed Lipinski’s rule with zero violations, were flexible and lipophilic, exhibited high gastrointestinal absorption, and could not permeate the blood-brain barrier. In conclusion, these compounds possess good anticancer and antibacterial potential.