Novel Straightforward One-Pot Synthesis and Characterization of 1-(2-Aminophenyl)-2,2,2-trifluoroethan-1-one Analogues

An easy one-pot synthesis of 1-(2-aminophenyl)-2,2,2-trifluoroethan-1-one derivatives in an Inconel autoclave with 52–91% yields is reported. This protocol provides a very straightforward, quick, easy-to-work-up, and economical approach. ¹H, ¹³C, ¹⁹F NMR, 2D NMR, and LCMS were used to confirm the structure of the synthesized compounds. The compound C₈H₅ClF₃NO (3b) exhibits a syn conformation for the F–C–C=O fragment with a torsion angle of 1.1(3)°. Additionally, there is an intramolecular N–H···O hydrogen bond that closes a six-membered ring. The molecules in crystal are connected into chains in the [010] direction by hydrogen bonds involving N–H···F and N–H···O interactions.