Synthesis and Analgesic Activity of Substituted N-Alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides

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发表日期：

2024年11月1日

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E. I. Denisova,
O. V. Zvereva,
D. V. Lipin,
R. R. Makhmudov,
I. N. Chernov,
E. S. Denislamova,
D. A. Shipilovskikh,
N. M. Igidov

摘要

Abstract

A series of new substituted derivatives of N-alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides were synthesized via the opening of the furan ring in substituted 3-N-5-aryl-2-oxofuran-3(2H)-ylidene-4-R¹-benzohydrazides under the action of various alkylamines. The in vivo analgesic activity and acute toxicity of the synthesized compounds were assessed to show that they have a pronounced analgesic activity and are almost nontoxic.